Cisplatin resistance in human ovarian cancer cells and its modulation by signaling pathway- and nuclear transcription factor NF kappa-B inhibition

Project leader: Jozef Duraj
Project duration: 2010 - 2012

Nowadays cisplatin represents one of the most effective chemotherapeutics for the treatment of human solid tumors. The development of resistance cause limitations in its efficacy. The study of relationships among diverse signaling/apoptotic molecules, transcription factors and resistance to anticancer drugs, molecular regulations of these processes and mutual interactions, opens new procedures for the development of effective chemotherapy in chemoresistant tumor cells. The aim of this project is, in sensitive- and resistant human ovarian carcinoma cells, to determine the relevance of markers related to cisplatin resistance, with respect to the study of signaling/apoptotic pathways, transcriptional regulation of resistance molecules, as molecular targets for the single- or combined chemotherapy. We assume that the obtained results expand the knowledge in this area and in the future will signify a benefit for clinical practice.

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